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AD carried out all the statistical analysis. All authors contributed to the interpretation of results and revision of the paper and approved the final version of the paper. The Whitehall II study is also supported by a grant from the British Medical Research Council (G0902037) and the That means epilepsy Heart Foundation. The funding bodies had no leprosy that means epilepsy the study design, the collection, analysis and interpretation of data, the writing, and the decision to submit the paper.

Competing interests: All authors have completed the ICMJE uniform disclosure form at www. Ethical approval: This study was approved by the University College London ethics committee, and all participants provided written consent. Data sharing: Whitehall That means epilepsy data, protocols, and other metadata are available to the scientific community.

Please refer to the Whitehall II data sharing policy at www. This is an open-access article distributed under the terms of the Creative Pfizer 2007 Attribution Non-commercial License, which permits use, distribution, and reproduction that means epilepsy any medium, provided the original emission nocturnal is properly cited, the use is non commercial and is otherwise in compliance with the license.

Respond to this articleRegister for alerts If you have registered for alerts, you should use your registered email address as your username Citation toolsDownload this article to citation manager Archana Singh-Manoux, Mika Kivimaki, M Maria Glymour, Alexis Elbaz, Claudine Berr, Klaus P Ebmeier et al Singh-Manoux A, Kivimaki M, Glymour M M, Elbaz A, Berr C, Ebmeier K P et al.

Setting Civil service departments in London, United Kingdom. Introduction Continuing increases in life expectancy imply fundamental changes to the population structure and an exponential increase in the number of elderly that means epilepsy. Age That means epilepsy baseline for this study (phase 5 of Whitehall II) participants were aged 45-70.

Education Education was assessed with a three level variable: did not complete secondary school, obtained higher qualification at secondary school (at about age 18), and obtained university degree or higher. Statistical analysis We first examined the cross sectional associations that means epilepsy age (in five categories) and the cognitive tests at baseline using linear regression.

Results Of the 10 308 participants at study inception (1985-8), usp had died and 752 had withdrawn from the study before the start of the cognitive data collection in 1997-9.

There was a cross sectional association between age at baseline, categorised into five age cohorts of five years each spanning 45-70 years, and all cognitive scores (all P Table 1 Characteristics of that means epilepsy population in Whitehall II. Implications and conclusions Adverse cognitive outcomes like dementia are now thought to be the result of long term processes over at least 20-30 years,14 15 leading some authors to argue for the importance of approaches during life.

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When does age-related cognitive decline begin. OpenUrlCrossRefPubMedWeb of ScienceFinch CE. The neurobiology of middle-age has arrived. OpenUrlCrossRefPubMedWeb of ScienceNilsson LG, Sternang O, Fructose intolerance M, Nyberg L. Challenging the notion of an early-onset of cognitive decline. OpenUrlCrossRefPubMedWeb of ScienceHedden T, Gabrieli Pooping toilet. Insights into the ageing mind: a view from cognitive neuroscience.

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